Pharmacokinetics of a spin-labeled rubomycin analog

Pharmacokinetics of a spin-labeled analog of rubomycin (ruboxyl) was studied. Differences were found in ruboxyl pharmacokinetics in normal and tumor-bearing animals. Most of the drug was excreted within 6 h. The differences in pharmacokinetics of ruboxyl and nitroxyl radical were established.

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Bibliographic Details
Published in:	Neoplasma Vol. 35; no. 2; pp. 185 - 190
Main Authors:	Konovalova, N P, Diatchkovskaya, R F, Kukushkina, G V, Volkova, L M, Varfolomeev, V N, Dombrovsky, L S, Shapiro, A B
Format:	Journal Article
Language:	English
Published:	Slovakia 1988
Subjects:	Animals Daunorubicin - analogs & derivatives Daunorubicin - pharmacokinetics Daunorubicin - therapeutic use Electron Spin Resonance Spectroscopy Liver - metabolism Mice Sarcoma 180 - drug therapy Sarcoma 180 - metabolism Tissue Distribution
Online Access:	Get full text
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Summary:	Pharmacokinetics of a spin-labeled analog of rubomycin (ruboxyl) was studied. Differences were found in ruboxyl pharmacokinetics in normal and tumor-bearing animals. Most of the drug was excreted within 6 h. The differences in pharmacokinetics of ruboxyl and nitroxyl radical were established.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0028-2685