Correlation of chlorpromazine levels in rat brain and serum with its hypothermic effect
The correlation between chlorpromazine (CPZ) levels in rat brain and serum with hypothermia was investigated. Even large differences between brain and serum concentrations of CPZ could be demonstrated at the two dosages of the drug investigated, the groups showed an identical hypothermic effect betw...
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| Published in: | Psychopharmacology communications Vol. 1; no. 4; p. 431 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
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United States
1975
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| Abstract | The correlation between chlorpromazine (CPZ) levels in rat brain and serum with hypothermia was investigated. Even large differences between brain and serum concentrations of CPZ could be demonstrated at the two dosages of the drug investigated, the groups showed an identical hypothermic effect between 5 to 30 minutes, with maximum hypothermia being reached 1 hour. It also appears that when brain concentrations of CPZ were lower than 1 mug/g, body temperature returned to normal. We could not demonstrate any preferential uptake of CPZ into the hypothalamus, the proposed site at which CPZ acts to cause hypothermia. |
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| AbstractList | The correlation between chlorpromazine (CPZ) levels in rat brain and serum with hypothermia was investigated. Even large differences between brain and serum concentrations of CPZ could be demonstrated at the two dosages of the drug investigated, the groups showed an identical hypothermic effect between 5 to 30 minutes, with maximum hypothermia being reached 1 hour. It also appears that when brain concentrations of CPZ were lower than 1 mug/g, body temperature returned to normal. We could not demonstrate any preferential uptake of CPZ into the hypothalamus, the proposed site at which CPZ acts to cause hypothermia. |
| Author | Wurzburger, R J Spector, S Kawashima, K |
| Author_xml | – sequence: 1 givenname: K surname: Kawashima fullname: Kawashima, K – sequence: 2 givenname: R J surname: Wurzburger fullname: Wurzburger, R J – sequence: 3 givenname: S surname: Spector fullname: Spector, S |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/1224011$$D View this record in MEDLINE/PubMed |
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| Snippet | The correlation between chlorpromazine (CPZ) levels in rat brain and serum with hypothermia was investigated. Even large differences between brain and serum... |
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| SubjectTerms | Animals Body Temperature - drug effects Brain Chemistry Chlorpromazine - analysis Chlorpromazine - blood Chlorpromazine - pharmacology Depression, Chemical Male Rats Time Factors |
| Title | Correlation of chlorpromazine levels in rat brain and serum with its hypothermic effect |
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