Evaluation of a clinical case definition of AIDS in African children

In July 1986, a provisional clinical case definition of AIDS in children, developed by the World Health Organization (WHO) for surveillance purposes in Africa, was tested on 159 patients hospitalized in the Department of Pediatrics at Mama Yemo Hospital, Kinshasa, Zaire. Twenty-one (13%) of these ch...

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Bibliographic Details
Published in:	AIDS (London) Vol. 1; no. 3; p. 151
Main Authors:	Colebunders, R I, Greenberg, A, Nguyen-Dinh, P, Francis, H, Kabote, N, Izaley, L, Davachi, F, Quinn, T C, Piot, P
Format:	Journal Article
Language:	English
Published:	England 01-09-1987
Subjects:	Acquired Immunodeficiency Syndrome - diagnosis Acquired Immunodeficiency Syndrome - immunology Africa Antibodies, Viral - analysis Child Child, Preschool Diagnostic Errors Evaluation Studies as Topic HIV - immunology HIV Antibodies Humans Infant World Health Organization Africa
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Summary:	In July 1986, a provisional clinical case definition of AIDS in children, developed by the World Health Organization (WHO) for surveillance purposes in Africa, was tested on 159 patients hospitalized in the Department of Pediatrics at Mama Yemo Hospital, Kinshasa, Zaire. Twenty-one (13%) of these children were seropositive for HIV. In this population, the clinical case definition of pediatric AIDS was found to be fairly specific (87%) but lacked sensitivity (35%). The positive predictive value for HIV seropositivity was 25%. This study suggests that it is more difficult to define AIDS clinically in children than in adults and that the utility of the proposed WHO clinical case definition for pediatric AIDS for surveillance of children's AIDS in Africa is limited.
ISSN:	0269-9370