Acute effects of human growth hormone on zinc, copper, calcium and magnesium metabolism in normal subjects

The acute effects of human growth hormone (hGH) on the metabolism of zinc, copper, calcium and magnesium ions was studied. Seven normal subjects were perfused iv with doses of 0.2 or 1.0 mg hGH over a period of 60 min. An increase in plasma zinc, calcium and magnesium, and a decrease in plasma coppe...

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Bibliographic Details
Published in:	Brazilian journal of medical and biological research Vol. 21; no. 1; p. 43
Main Authors:	Brandão-Neto, J, Kimachi, T, Veríssimo, J M, Shuhama, T, Marchini, J S, Antunes-Rodrigues, J
Format:	Journal Article
Language:	English
Published:	Brazil 1988
Subjects:	Adolescent Adult Calcium - blood Calcium - metabolism Calcium - urine Copper - blood Copper - metabolism Copper - urine Female Growth Hormone - administration & dosage Growth Hormone - pharmacology Humans Infusions, Intravenous Magnesium - blood Magnesium - metabolism Magnesium - urine Zinc - blood Zinc - metabolism Zinc - urine
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Summary:	The acute effects of human growth hormone (hGH) on the metabolism of zinc, copper, calcium and magnesium ions was studied. Seven normal subjects were perfused iv with doses of 0.2 or 1.0 mg hGH over a period of 60 min. An increase in plasma zinc, calcium and magnesium, and a decrease in plasma copper levels was noted for the 0.2 mg dose, and these effects were reversed for the 1.0 mg dose although no urine changes occurred. Plasma mobilization of these ions appears to be related to their roles as essential physiological modulators for the action of hGH.
ISSN:	0100-879X