Dialysis enhances renal epithelial proliferations

Study of 115 kidneys from 60 patients with chronic renal failure maintained by dialysis for two months to five years revealed an unexpected number and variety of epithelial proliferative processes, several types of which are hitherto unreported. Proliferative activity was defined either by the prese...

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Bibliographic Details
Published in:	Archives of pathology & laboratory medicine (1976) Vol. 104; no. 4; p. 192
Main Authors:	McManus, J F, Hughson, M D, Hennigar, G R, Fitts, C T, Rajagopalan, P R, Williams, A V
Format:	Journal Article
Language:	English
Published:	United States 01-04-1980
Subjects:	Epithelium - pathology Humans Hyperplasia Kidney - pathology Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Kidney Glomerulus - pathology Kidney Neoplasms - etiology Kidney Tubules - pathology Muscle, Smooth - pathology Regeneration Renal Dialysis
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Summary:	Study of 115 kidneys from 60 patients with chronic renal failure maintained by dialysis for two months to five years revealed an unexpected number and variety of epithelial proliferative processes, several types of which are hitherto unreported. Proliferative activity was defined either by the presence of epithelial structures in ectopic situations, continuity with existing structures being demonstrable by serial sections, or by mitotic figures, or by both. The tendency for renal carcinoma development may relate to these dialysis-related epithelial proliferations originating in both glomerular and tubular epithelia. Enhanced renal epithelial proliferative capacity in dialysis may be employable in the experimental study of renal regeneration and in the therapy of patients with preterminal renal disease.
ISSN:	0003-9985