Elevated levels of the chromosomal protein HMG 17 in chronic myelogenic leukemia

The High Mobility Group protein HMG 17 has been isolated from human leukemia cells obtained from patients with chronic myelogenic leukemia (CML). The level of expression of HMG 17 was investigated Human leukemia cells have three times more HMG 17 than normal human leukocytes. Three other malignant t...

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Bibliographic Details
Published in:	Biochemistry and molecular biology international Vol. 36; no. 4; p. 803
Main Authors:	Kondos, H, Anastasiadou, E, Photopoulou, A, Cary, P, Aleporou-Marinou, V, Pataryas, T
Format:	Journal Article
Language:	English
Published:	England 01-07-1995
Subjects:	Amino Acids - analysis Animals Cattle Chromatography, High Pressure Liquid Electrophoresis, Gel, Two-Dimensional Electrophoresis, Polyacrylamide Gel High Mobility Group Proteins - biosynthesis High Mobility Group Proteins - blood High Mobility Group Proteins - isolation & purification Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - blood Leukocytes - metabolism Molecular Weight Reference Values Thymus Gland - metabolism
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Summary:	The High Mobility Group protein HMG 17 has been isolated from human leukemia cells obtained from patients with chronic myelogenic leukemia (CML). The level of expression of HMG 17 was investigated Human leukemia cells have three times more HMG 17 than normal human leukocytes. Three other malignant tissues were also compared. Two of these breast adenocarcinoma and other intestine- also exhibit higher amounts of HMG 17. The elevated expression of HMG 17 suggests that the level of the protein may be associated with rates of cellular proliferation.
ISSN:	1039-9712