Effective control of cisplatin-induced nausea using high-dose steroids and droperidol

Seventy-three consecutive patients receiving cisplatin-containing chemotherapy regimens were treated with an initial dose of chlorpromazine (25 mg im), droperidol (1 mg iv, then 1 mg sc every 4 hours), and methylprednisolone (250 mg every 4 hours for four doses). Twenty patients received a combinati...

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Bibliographic Details
Published in:	Cancer treatment reports Vol. 66; no. 2; p. 243
Main Authors:	Mason, B A, Dambra, J, Grossman, B, Catalano, R B
Format:	Journal Article
Language:	English
Published:	United States 01-02-1982
Subjects:	Adult Aged Cisplatin - adverse effects Droperidol - administration & dosage Drug Administration Schedule Drug Therapy, Combination Humans Methylprednisolone - therapeutic use Middle Aged Nausea - chemically induced Nausea - prevention & control Steroids - administration & dosage Vomiting - prevention & control
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Summary:	Seventy-three consecutive patients receiving cisplatin-containing chemotherapy regimens were treated with an initial dose of chlorpromazine (25 mg im), droperidol (1 mg iv, then 1 mg sc every 4 hours), and methylprednisolone (250 mg every 4 hours for four doses). Twenty patients received a combination chemotherapy protocol that included cisplatin at a dose of 40 mg/m2 iv (group 1) and 53 patients received a protocol that included cisplatin at a dose of 120 mg/m2 iv (group 2). The median age of all the patients was 58 years. Seventy-five percent of the patients in group 1 and 45% of those in group 2 had no vomiting at all; the remainder had limited and tolerable vomiting. These results in a group of elderly patients compare favorably with trials of other antiemetic programs.
ISSN:	0361-5960