Comparative assessment of beta-adrenoceptor blocking agents as simple competitive antagonists in isolated heart muscle: similarity of inotropic and chronotropic blocking potencies against isoproterenol

The pattern of antagonism between isoproterenol and various beta-adrenoceptor blocking agents was explored in spontaneously beating right atria and in driven left atrial strips from kittens and guinea pigs. The onset of beta-adrenoceptor blockade is usually very slow in such preparations; incubation...

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Bibliographic Details

Published in:	Naunyn-Schmiedeberg's archives of pharmacology Vol. 311; no. 3; pp. 219 - 236
Main Authors:	Kaumann, A J, McInerny, T K, Gilmour, D P, Blinks, J R
Format:	Journal Article
Language:	English
Published:	Germany 01-04-1980
Subjects:	Adrenergic beta-Antagonists - pharmacology Animals Bupranolol - pharmacology Cats Dose-Response Relationship, Drug Female Guinea Pigs Heart Rate - drug effects In Vitro Techniques Isoproterenol - antagonists & inhibitors Male Myocardial Contraction - drug effects Sotalol - pharmacology Time Factors
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