Valinomycin-induced modulation of adriamycin resistance and cationic probe distribution in MCF-7 cell lines

In vitro restoration of adriamycin sensitivity in a resistant human breast tumor cell line was obtained by continuous exposure to nanomolar nontoxic valinomycin concentrations. Seven-day treatment with nanomolar valinomycin concentrations caused a slight increase of the signal of the cationic fluore...

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Bibliographic Details
Published in:	Biochemistry international Vol. 25; no. 4; p. 593
Main Authors:	Crifò, C, Capuozzo, E, Cucco, C, Zupi, G, Salerno, C
Format:	Journal Article
Language:	English
Published:	Australia 01-11-1991
Subjects:	Carbocyanines Cell Division - drug effects Doxorubicin - administration & dosage Doxorubicin - pharmacology Drug Resistance Drug Synergism Fluorescent Dyes Humans Tumor Cells, Cultured - drug effects Valinomycin - administration & dosage Valinomycin - pharmacology
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Summary:	In vitro restoration of adriamycin sensitivity in a resistant human breast tumor cell line was obtained by continuous exposure to nanomolar nontoxic valinomycin concentrations. Seven-day treatment with nanomolar valinomycin concentrations caused a slight increase of the signal of the cationic fluorescent cyanine probe DiOC5(3) but did not appreciably affect adriamycin incorporation in the cells. A marked increase of the DiOC5(3) signal was obtained in the presence of micromolar valinomycin concentrations, which were incompatible with the in vitro cellular growth.
ISSN:	0158-5231