Studies on the sympathomimetic effects of guanoxan on smooth muscles of rat

In anococcygeus muscle and vas deferens preparations of rat, guanidinomethyl-2-benzo-(1,4)-dioxane (guanoxan) potentiated responses to norepinephrine (NF) in concentrations which exerted a neurone blocking effect. The potentiation was significantly reduced in reserpinized preparations and was abolis...

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Bibliographic Details
Published in:	Arzneimittel-Forschung Vol. 28; no. 6; p. 997
Main Authors:	Joshi, M, Joshi, N J, Shah, D S, Hemavathi, K G, Gulati, O D
Format:	Journal Article
Language:	English
Published:	Germany 1978
Subjects:	Animals Drug Synergism Guanidines - pharmacology In Vitro Techniques Male Muscle Contraction - drug effects Muscle, Smooth - drug effects Norepinephrine - pharmacology Rats Sympatholytics Sympathomimetics
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Summary:	In anococcygeus muscle and vas deferens preparations of rat, guanidinomethyl-2-benzo-(1,4)-dioxane (guanoxan) potentiated responses to norepinephrine (NF) in concentrations which exerted a neurone blocking effect. The potentiation was significantly reduced in reserpinized preparations and was abolished in the presence of nialamide. The possible mechanisms of potentiation have been discussed. Higher concentrations of guanoxan produced concentration-related contractions. The contractions were significantly less in reserpinized preparations. Phentolamine both prevented and reversed the contractions while methysergide was ineffective in this respect. Thus the effect of guanoxan appears to be mediated through the activation of alpha-receptors by the released NE.
ISSN:	0004-4172