Oscillatory nature of DNA, RNA, protein and lipid metabolisms in antigen-stimulated lymphocytes

Oscillatory nature of DNA, RNA, protein and lipid metabolisms in antigen-stimulated lymphocytes

The primary immune response in inbred strain C3H/He to SRBC, or BSA is induced. The DNA, RNA, lipid precursor uptakes and total proteins are studied for 14 successive days following immunization, in splenic lymphocytes. Significant variations are noticed in the course of immune response of stimulate...

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Bibliographic Details
Published in:Chronobiologia Vol. 6; no. 1; p. 9
Main Authors: Vaillier, J, Donner, M
Format: Journal Article
Language:English
Published: Italy 01-01-1979
Subjects:
Animals
DNA - metabolism
Erythrocytes - immunology
Lipid Metabolism
Lymphocyte Activation
Lymphocytes - immunology
Lymphocytes - metabolism
Male
Mice
Periodicity
Proteins - metabolism
RNA - metabolism
Serum Albumin, Bovine - immunology
Spleen - immunology
Spleen - metabolism
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Summary:The primary immune response in inbred strain C3H/He to SRBC, or BSA is induced. The DNA, RNA, lipid precursor uptakes and total proteins are studied for 14 successive days following immunization, in splenic lymphocytes. Significant variations are noticed in the course of immune response of stimulated lymphocytes concerning their DNA, RNA, lipid and protein metabolisms respectively. The results reveal that there are several wave-metabolisms. The kinetic studies further indicate that course of different metabolisms would be of oscillatory nature. The activity peaks of synthesis may vary according to different antigens. Oscillatory systems would be 'excited' by antigenic stimulation. These results and hypotheses are discussed here.
ISSN:0390-0037