Cytological characteristics of a bovine kidney cell culture chronically infected with foot-and-mouth disease virus (author's transl)

Cytological characteristics of a bovine kidney cell culture chronically infected with foot-and-mouth disease virus (author's transl)

A virus-carrier state was observed in the process of subcultivation of foot-and-mouth disease virus-infected calf kidney cell culture. Cytologically, the chronically infected culture differed from the control culture by the presence of a large number of syncytial cells which did not die in acute inf...

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Bibliographic Details
Published in:Voprosy virusologiĭ no. 5; p. 602
Main Authors: Kudriavtserva, G A, Ol'shevskaia, T I, Driagalin, N N, Khesin, Ia E
Format: Journal Article
Language:Russian
Published: Russia (Federation) 01-09-1975
Subjects:
Animals
Antigens, Viral - analysis
Aphthovirus - immunology
Aphthovirus - pathogenicity
Cattle
Cell Nucleus
Cells, Cultured - cytology
Culture Media
Cytological Techniques
Cytopathogenic Effect, Viral
Fluorescent Antibody Technique
Karyometry
Kidney - cytology
Kidney - metabolism
Time Factors
Virus Replication
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Summary:A virus-carrier state was observed in the process of subcultivation of foot-and-mouth disease virus-infected calf kidney cell culture. Cytologically, the chronically infected culture differed from the control culture by the presence of a large number of syncytial cells which did not die in acute infection because of poor susceptibility to the virus. Chronic infection appeared to be maintained by occasionaly polygonal cells which retained the initial sesceptiblity to foot-and-mouth disease virus. The number of such cells did not exceed 1--4% and by the 9th passage they disappeared completely. At this time the experimental culture did not differ from control cytologically and cytochemically.
ISSN:0507-4088