Peri-operative radiotherapy for the prevention of post-operative fibrosis on rats

• Published in: International journal of radiation research Vol. 16; no. 4; pp. 481 - 485
• Main Authors: Kiziltan, H S, Eris, A H, Meral, I, Seyithanoglu, H, Dundar, T, Eren, F, Unver, N, Aydin, T, Mayadagli, A, Bayir, A G, Celikten, M
• Format: Journal Article
• Language: English
• Published: Tehran Novin Medical Radiation Institute 01-10-2018
• Subjects: Albinism; Animals; Back surgery; Cell growth; Corticosteroids; Electron beams; Fibroblasts; Fibrosis; Gels; Laboratory animals; Neurosurgery; Prevention; Radiation dosage; Radiation therapy; Statistical analysis; Taping; Istanbul Turkey; Turkey
• ISSN: 2322-3243; 2345-4229
• DOI: 10.18869/acadpub.ijrr.16.4.481

Background: Post-operative fibrosis related pains and functional anomalies can be serious problems for patients. Radiotherapy (RT) could inhibit fibrosis which may occurs post- operation especially following laminectomy. Therefore, this study was designed to investigate the effect of peri-operative RT on the prevention of post-operative fibrosis and scar formation on rats. Materials and Methods: Twenty three male Wistar albino rats, were divided into three experimental groups. Laminectomy was performed to L3 and L4 lomber vertebral regions of group L and L+R rats. The rats in L+R group in addition to this procedure also received peri-operative RT on the laminectomy area. A total dose of 700 cGy of RT was applied as a single fraction using electrons. Control rats received no treatment. A rotarod test was performed at 20, 30 and 40 rpm/min speed rates to determine the physical performances of the rats. Results: The results have indicated statistically significant (P<0.05) differences for the 30 rpm/min rotarod test between the L and L+R groups. Histopatologically, significant differences were observed in epidural fibrosis, fibroblast cell density and arachnoid adhesion between the L and L+R groups. Conclusion: It was concluded that peri-operative RT may provide a significant advantage for prevention post-laminectomic of scar tissue formation.