Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19
The recent COVID-19 pandemic caused by SARS-CoV-2 affected more than six million people and caused thousands of deaths. The lack of effective drugs or vaccines against SARS-CoV-2 further worsened the situation. This review is focused on the identification of molecules that may inhibit viral entry in...
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| Published in: | Acta bio-medica : Atenei Parmensis Vol. 91; no. 13-S; p. e2020008 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Italy
Mattioli 1885
09-11-2020
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| Abstract | The recent COVID-19 pandemic caused by SARS-CoV-2 affected more than six million people and caused thousands of deaths. The lack of effective drugs or vaccines against SARS-CoV-2 further worsened the situation. This review is focused on the identification of molecules that may inhibit viral entry into host cells by endocytosis.
We performed the literature search for these natural compounds in the articles indexed in PubMed.
Natural products against viral infections have been gaining importance in recent years. Specific natural compounds like phytosterols, polyphenols, flavonoids, citrus, galangal, curcuma and hydroxytyrosol are being analyzed to understand whether they could inhibit SARS-CoV-2.
We reviewed natural compounds with potential antiviral activity against SARS-CoV-2 that could be used as a treatment for COVID-19. |
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| AbstractList | The recent COVID-19 pandemic caused by SARS-CoV-2 affected more than six million people and caused thousands of deaths. The lack of effective drugs or vaccines against SARS-CoV-2 further worsened the situation. This review is focused on the identification of molecules that may inhibit viral entry into host cells by endocytosis.
We performed the literature search for these natural compounds in the articles indexed in PubMed.
Natural products against viral infections have been gaining importance in recent years. Specific natural compounds like phytosterols, polyphenols, flavonoids, citrus, galangal, curcuma and hydroxytyrosol are being analyzed to understand whether they could inhibit SARS-CoV-2.
We reviewed natural compounds with potential antiviral activity against SARS-CoV-2 that could be used as a treatment for COVID-19. |
| Author | Bertelli, Matteo Bressan, Simone Ergoren, Mahmut C Dhuli, Kristjana Dundar, Munis Beccari, Tommaso Kiani, Aysha Karim Anpilogov, Kyrylo Dautaj, Astrit |
| AuthorAffiliation | 7 DESAM Institute, Near East University, Nicosia, Cyprus 3 MAGI’S LAB, Rovereto (TN), Italy 6 Department of Medical Biology, Faculty of Medicine, Near East University, Nicosia, Cyprus 2 EBTNA-LAB, Rovereto (TN), Italy 1 MAGI EUREGIO, Bolzano, Italy 4 Department of Medical Genetics, Erciyes University, Kayseri, Turkey 5 Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy |
| AuthorAffiliation_xml | – name: 3 MAGI’S LAB, Rovereto (TN), Italy – name: 5 Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy – name: 2 EBTNA-LAB, Rovereto (TN), Italy – name: 1 MAGI EUREGIO, Bolzano, Italy – name: 6 Department of Medical Biology, Faculty of Medicine, Near East University, Nicosia, Cyprus – name: 4 Department of Medical Genetics, Erciyes University, Kayseri, Turkey – name: 7 DESAM Institute, Near East University, Nicosia, Cyprus |
| Author_xml | – sequence: 1 givenname: Aysha Karim surname: Kiani fullname: Kiani, Aysha Karim email: ayshakiani@gmail.com organization: MAGI EUREGIO, Bolzano, Italy. ayshakiani@gmail.com – sequence: 2 givenname: Kristjana surname: Dhuli fullname: Dhuli, Kristjana email: support.genetica@assomagi.org organization: EBTNA-LAB, Rovereto (TN), Italy. support.genetica@assomagi.org – sequence: 3 givenname: Kyrylo surname: Anpilogov fullname: Anpilogov, Kyrylo email: kirill.anpilogov@assomagi.org organization: MAGI'S LAB, Rovereto (TN), Italy. kirill.anpilogov@assomagi.org – sequence: 4 givenname: Simone surname: Bressan fullname: Bressan, Simone email: simone.bressan@assomagi.org organization: MAGI'S LAB, Rovereto (TN), Italy. simone.bressan@assomagi.org – sequence: 5 givenname: Astrit surname: Dautaj fullname: Dautaj, Astrit email: stefano.paolacci@assomagi.org organization: EBTNA-LAB, Rovereto (TN), Italy. stefano.paolacci@assomagi.org – sequence: 6 givenname: Munis surname: Dundar fullname: Dundar, Munis email: stefano.paolacci@assomagi.org organization: Department of Medical Genetics, Erciyes University, Kayseri, Turkey. stefano.paolacci@assomagi.org – sequence: 7 givenname: Tommaso surname: Beccari fullname: Beccari, Tommaso email: stefano.paolacci@assomagi.org organization: Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy. stefano.paolacci@assomagi.org – sequence: 8 givenname: Mahmut C surname: Ergoren fullname: Ergoren, Mahmut C email: stefano.paolacci@assomagi.org organization: Department of Medical Biology, Faculty of Medicine, Near East University, Nicosia, Cyprus; DESAM Institute, Near East University, Nicosia, Cyprus. stefano.paolacci@assomagi.org – sequence: 9 givenname: Matteo surname: Bertelli fullname: Bertelli, Matteo email: matteo.bertelli@assomagi.org organization: MAGI EUREGIO, Bolzano, Italy; EBTNA-LAB, Rovereto (TN), Italy; MAGI'S LAB, Rovereto (TN), Italy. matteo.bertelli@assomagi.org |
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| Snippet | The recent COVID-19 pandemic caused by SARS-CoV-2 affected more than six million people and caused thousands of deaths. The lack of effective drugs or vaccines... |
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| SubjectTerms | Antiviral Agents - therapeutic use Betacoronavirus Biological Factors - therapeutic use Coronavirus Infections - drug therapy COVID-19 COVID-19 Drug Treatment Endocytosis - drug effects Humans Original Pandemics Pneumonia, Viral - drug therapy SARS-CoV-2 |
| Title | Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19 |
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