Management of proliferative lupus nephritis

Kidney abnormalities are present in up to 60% of patients with systemic lupus. Proliferative lupus nephritis is one of the most serious manifestation and requires rapid recognition and treatment. Kidney biopsy plays an essential role in the management and prognosis of proliferative lupus nephritis....

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Bibliographic Details
Published in:	Panminerva medica Vol. 58; no. 4; p. 286
Main Authors:	Monroy Trujillo, Jose M, Fine, Derek M
Format:	Journal Article
Language:	English
Published:	Italy 01-12-2016
Subjects:	Adrenal Cortex Hormones - therapeutic use Biological Products - therapeutic use Biopsy Cell Proliferation Cyclophosphamide - therapeutic use Humans Kidney - pathology Lupus Nephritis - drug therapy Lupus Nephritis - pathology Mycophenolic Acid - therapeutic use
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Summary:	Kidney abnormalities are present in up to 60% of patients with systemic lupus. Proliferative lupus nephritis is one of the most serious manifestation and requires rapid recognition and treatment. Kidney biopsy plays an essential role in the management and prognosis of proliferative lupus nephritis. Treatment includes and induction phase with systemic steroids and antiproliferative therapy. This is followed by a maintenance phase to prevent the risk of relapses. Cytotoxic therapy carries significant side effects and complications. Further research is needed to establish the role of biologics in the management of proliferative lupus nephritis.
ISSN:	1827-1898