Development of Human Recombinant Leptospirosis Vaccines

Leptospirosis is a bacterial zoonotic disease with significant impact on health all over the world. Currently, bacterins are the only vaccines available for prevention of this disease, despite several drawbacks. In an effort to develop a more effective vaccine against leptospirosis, reverse and stru...

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Bibliographic Details
Published in:	Methods in molecular biology (Clifton, N.J.) Vol. 2410; p. 325
Main Authors:	de Oliveira, Natasha Rodrigues, Oliveira, Thaís Larré, Jorge, Sérgio, Dellagostin, Odir Antônio
Format:	Journal Article
Language:	English
Published:	United States 2022
Subjects:	Antigens, Bacterial Bacterial Vaccines Humans Leptospira - genetics Leptospira - immunology Leptospirosis - prevention & control Vaccines, Synthetic - genetics Experimental infection Recombinant protein Structural modeling Leptospira
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Summary:	Leptospirosis is a bacterial zoonotic disease with significant impact on health all over the world. Currently, bacterins are the only vaccines available for prevention of this disease, despite several drawbacks. In an effort to develop a more effective vaccine against leptospirosis, reverse and structural vaccinology have been applied to design recombinant constructions composed of leptospiral surface-exposed antigens. Herein, we describe a protocol for design and development of Leptospirosis recombinant vaccines using immunoinformatic approaches.
ISSN:	1940-6029
DOI:	10.1007/978-1-0716-1884-4_16