Swine Model of Coronary Artery Dissection

Coronary artery dissection (CAD) is the intimal tearing of the coronary arterial wall and can be iatrogenic, spontaneous, or traumatic in origin. CAD is a rare but challenging condition that can cause significant hemodynamic compromise. Management strategies for CAD, such as the use of mechanical ci...

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Bibliographic Details
Published in:	Methods in molecular biology (Clifton, N.J.) Vol. 2803; p. 219
Main Authors:	Leonard, Kyra, Mavropoulos, Spyros A, Mazurek, Renata, Ishikawa, Kiyotake
Format:	Journal Article
Language:	English
Published:	United States 2024
Subjects:	Animals Aortic Dissection Coronary Artery Disease - pathology Coronary Vessel Anomalies Coronary Vessels - pathology Disease Models, Animal Humans Swine Vascular Diseases - congenital Vascular Diseases - etiology Vascular Diseases - pathology Vascular Diseases - therapy Coronary angiography Intima Spontaneous coronary artery dissection Large animal Pseudolumen
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Summary:	Coronary artery dissection (CAD) is the intimal tearing of the coronary arterial wall and can be iatrogenic, spontaneous, or traumatic in origin. CAD is a rare but challenging condition that can cause significant hemodynamic compromise. Management strategies for CAD, such as the use of mechanical circulatory support devices, are available in the clinical setting. However, the incidence, etiology, and optimal management of CAD are not well-defined, emphasizing the need for adequate animal models in preclinical studies. Large animal models provide the human-like conditions necessary for testing and development of potential treatment strategies. In this chapter, we describe a method for the creation of a CAD swine model.
ISSN:	1940-6029
DOI:	10.1007/978-1-0716-3846-0_16