Biointerfaces promoting tissue healing
Cell adhesion to extracellular matrices plays central roles in development and the formation, maintenance and repair of numerous tissues, including bone, muscle, and cartilage. Moreover, cell adhesion to adsorbed proteins and adhesive sequences engineered on surfaces is important to biomaterials, ti...
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Published in: | Journal of musculoskeletal & neuronal interactions Vol. 7; no. 4; p. 332 |
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Main Authors: | , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
Greece
01-10-2007
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Subjects: | |
Online Access: | Get full text |
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Summary: | Cell adhesion to extracellular matrices plays central roles in development and the formation, maintenance and repair of numerous tissues, including bone, muscle, and cartilage. Moreover, cell adhesion to adsorbed proteins and adhesive sequences engineered on surfaces is important to biomaterials, tissue engineering, and biotechnological applications. Cell adhesion to extracellular matrix proteins is primarily mediated by the integrin family of adhesion receptors. In addition to anchoring cells, supporting cell spreading and migration, integrins provide signals that direct cell survival, proliferation, and differentiation. Because of the critical importance of cell adhesion, biomimetic strategies have focused on generating surfaces that present short bioadhesive motifs, such as the integrin-binding motif arginine-glycine-aspartic acid (RGD) from fibronectin (FN), to promote cell adhesion. While these engineered supports promote adhesive activities in vitro, healing responses in in vivo models have been marginal. We hypothesize that these sub-optimal responses to these peptide-tethered surfaces arise from reduced biological activity compared to the native ligand, lack of specificity among integrins, and inability to bind non-RGD integrins. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1108-7161 |