HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells

Growth of human breast cells is closely regulated by steroid hormone as well as peptide hormone receptors. Members of both receptor classes are important prognostic factors in human breast cancer. Clinical data indicate that overexpression of the HER-2 gene is associated with an estrogen receptor-ne...

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Bibliographic Details
Published in:	Oncogene Vol. 10; no. 12; p. 2435
Main Authors:	Pietras, R J, Arboleda, J, Reese, D M, Wongvipat, N, Pegram, M D, Ramos, L, Gorman, C M, Parker, M G, Sliwkowski, M X, Slamon, D J
Format:	Journal Article
Language:	English
Published:	England 15-06-1995
Subjects:	Animals Breast Neoplasms - metabolism Breast Neoplasms - pathology Carrier Proteins - pharmacology Cell Division - drug effects Cell Nucleus - metabolism Down-Regulation Drug Resistance Estradiol - pharmacology Estrogens - pharmacology Glycoproteins - pharmacology Humans Mice Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Neuregulin-1 Phosphorylation Receptor, Epidermal Growth Factor - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Tamoxifen - pharmacology Tumor Cells, Cultured
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