Treatment of herpes labialis with acyclovir. Review of three clinical trials

Three trials with acyclovir in the treatment of recurrent herpes labialis in the same patient population are reviewed. In the first trial, oral acyclovir capsules, five times per day for five days, were shown to be of significant benefit for some parameters of cutaneous resolution in three successiv...

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Bibliographic Details
Published in:	The American journal of medicine Vol. 85; no. 2A; p. 39
Main Authors:	Raborn, G W, McGaw, W T, Grace, M, Percy, J
Format:	Journal Article
Language:	English
Published:	United States 29-08-1988
Subjects:	Acyclovir - administration & dosage Acyclovir - therapeutic use Adult Clinical Trials as Topic Double-Blind Method Herpes Labialis - drug therapy Humans Placebos Random Allocation
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Summary:	Three trials with acyclovir in the treatment of recurrent herpes labialis in the same patient population are reviewed. In the first trial, oral acyclovir capsules, five times per day for five days, were shown to be of significant benefit for some parameters of cutaneous resolution in three successive episodes. Topical formulations were evaluated in two separate trials; 5 percent acyclovir in a modified aqueous cream base exhibited favorable trends, but 5 percent acyclovir in a polyethylene base was ineffective. A high dose of oral acyclovir may offer the most effective method of control of recurrent herpes labialis.
ISSN:	0002-9343