Tolerance of perinidatory primate embryos to RU 486 exposure in vitro and in vivo

Monkey embryos were exposed to RU 486 both in vitro and in vivo (with and without progesterone therapy) in the perinidatory interval. These primate embryos were highly tolerant of RU 486, except when RU 486 alone terminated early pregnancy. There were no indications of teratogenicity in this limited...

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Bibliographic Details
Published in:	Contraception (Stoneham) Vol. 41; no. 1; p. 85
Main Authors:	Wolf, J P, Chillik, C F, Dubois, C, Ulmann, A, Baulieu, E E, Hodgen, G D
Format:	Journal Article
Language:	English
Published:	United States 01-01-1990
Subjects:	Animals Cell Survival Culture Techniques Embryo Implantation Embryo, Mammalian - drug effects Embryonic and Fetal Development - drug effects Female Humans Macaca Mifepristone - pharmacology Pregnancy Progesterone - pharmacology
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Summary:	Monkey embryos were exposed to RU 486 both in vitro and in vivo (with and without progesterone therapy) in the perinidatory interval. These primate embryos were highly tolerant of RU 486, except when RU 486 alone terminated early pregnancy. There were no indications of teratogenicity in this limited trial when the embryos were exposed to RU 486 either before implantation (10(-7)M in 24-hour cultures) or during the immediate post-implantation interval (50 mg orally/day; days 32 to 39 LMP).
ISSN:	0010-7824
DOI:	10.1016/0010-7824(90)90129-J