Dose-dependent vitamin D3, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3-induced hypercalcemia and hyperphosphatemia, and the correlative changes in the activity of ultimobranchial and parathyroid glands of the toad, Bufo andersoni Boulenger

Vitamin D3, 25(OH) vitamin D3 and 1,25 (OH)2D3 were administered daily to unfed male Bufo andersoni for 15 days which resulted in a significant hypercalcemia and hyperphosphatemia in a dose-dependent fashion. 1,25(OH)2D3 is more potent than the other metabolites. The treatment activated ultimobranch...

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Bibliographic Details
Published in:	Biological structures and morphogenesis Vol. 4; no. 4; p. 174
Main Authors:	Swarup, K, Pandey, A K, Hasan, N, Das, V K
Format:	Journal Article
Language:	English
Published:	France 1992
Subjects:	Animals Bufonidae Calcifediol - pharmacology Calcitriol - pharmacology Calcium - blood Cholecalciferol - pharmacology Dose-Response Relationship, Drug Hypercalcemia - blood Hypercalcemia - chemically induced Male Parathyroid Glands - drug effects Parathyroid Glands - metabolism Phosphates - blood Ultimobranchial Body - drug effects Ultimobranchial Body - metabolism
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Summary:	Vitamin D3, 25(OH) vitamin D3 and 1,25 (OH)2D3 were administered daily to unfed male Bufo andersoni for 15 days which resulted in a significant hypercalcemia and hyperphosphatemia in a dose-dependent fashion. 1,25(OH)2D3 is more potent than the other metabolites. The treatment activated ultimobranchial gland but induced degenerative changes in parathyroid of the toads.
ISSN:	0989-8972