Effect of peptide Lys-Glu on interleukin-2 gene expression in lymphocytes

Lys-Glu in vitro stimulated interleukin-2 gene expression in mouse spleen lymphocytes. This effect depended on peptide concentration and duration of treatment. It is hypothesized that this peptide is the shortest regulatory fragment promoting the transport of trans-acting factors into the nucleus. I...

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 130; no. 9; pp. 898 - 899
Main Authors:	Khavinson, V K, Morozov, V G, Malinin, V V, Kazakova, T B, Korneva, E A
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-09-2000
Subjects:	Animals Cytokines Gene expression Gene Expression Regulation - drug effects Interleukin-2 - genetics Interleukin-2 - immunology Lymphocytes Lymphocytes - drug effects Lymphocytes - immunology Male Mice Mice, Inbred CBA Peptides Peptides - pharmacology
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Summary:	Lys-Glu in vitro stimulated interleukin-2 gene expression in mouse spleen lymphocytes. This effect depended on peptide concentration and duration of treatment. It is hypothesized that this peptide is the shortest regulatory fragment promoting the transport of trans-acting factors into the nucleus. It can not be excluded that Lys-Glu is a structural component of trans-acting factor active centers, which are necessary for the activation of interleukin-2 gene transcription in lymphocytes.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1015382732640