Successful treatment of hemophagocytic lymphohistiocytosis and disseminated intravascular coagulation secondary to histoplasmosis in a patient with HIV/AIDS

• Published in: Biomédica Vol. 36; pp. 9 - 14
• Main Authors: Nieto, John Fredy, Gómez, Sandra Milena, Moncada, Diana Carolina, Serna, Lina María, Hidrón, Alicia Inés
• Format: Journal Article
• Language: English; Spanish
• Published: Colombia 01-04-2016
• Subjects: Acquired Immunodeficiency Syndrome - complications; Acquired Immunodeficiency Syndrome - microbiology; Amphotericin B - chemistry; Amphotericin B - pharmacology; Disseminated Intravascular Coagulation - complications; Disseminated Intravascular Coagulation - microbiology; Disseminated Intravascular Coagulation - virology; Histoplasmosis - complications; Humans; Lymphohistiocytosis, Hemophagocytic - diagnosis; Lymphohistiocytosis, Hemophagocytic - microbiology; Lymphohistiocytosis; histoplasmosis; disseminated intravascular coagulation; hemophagocytic; acquired immunodeficiency syndrome
• ISSN: 0120-4157
• DOI: 10.7705/biomedica.v36i2.2797

Haemophagocytic lymphohistiocytosis is an uncommon syndrome that results from an uncontrolled activation of macrophages and lymphocytes resulting in the compromise of multiple organs that is potentially fatal without timely treatment. It can be hereditary or a secondary result of infectious processes, neoplasms or autoimmune conditions. We present the case of a patient with HIV/AIDS who developed hemophagocytic lymphohistiocytosis as well as disseminated intravascular coagulation associated with histoplasmosis and who was successfully treated with amphotericin B, steroids and transitory dialytic support.