Long-term outcomes of adult chronic idiopathic hydrocephalus treated with a ventriculo-peritoneal shunt

• Published in: Neurologia (Barcelona, Spain) Vol. 32; no. 4; p. 205
• Main Authors: Illán-Gala, I, Pérez-Lucas, J, Martín-Montes, A, Máñez-Miró, J, Arpa, J, Ruiz-Ares, G
• Format: Journal Article
• Language: English; Spanish
• Published: Spain 01-05-2017
• Subjects: Age Factors; Aged; Female; Humans; Hydrocephalus - complications; Hydrocephalus - surgery; Hypertension - etiology; Longitudinal Studies; Male; Prospective Studies; Risk Factors; Spain; Treatment Outcome; Ventriculoperitoneal Shunt - methods; Epidemiología; Ventriculo-peritoneal shunt; Chronic adult hydrocephalus; Treatment; Hidrocefalia crónica del adulto; Normal pressure hydrocephalus; Tratamiento; Hidrocefalia normotensiva; Derivación ventrículo-peritoneal; Epidemiology
• ISSN: 1578-1968
• DOI: 10.1016/j.nrl.2015.10.002

Adult chronic idiopathic hydrocephalus (ACIH) is a cause of dementia that can be treated by implanting a ventriculo-peritoneal shunt (VPS). We aim to study clinical and functional outcomes in patients with ACIH corrected with a VPS.
Observational cohort study of patients diagnosed with probable ACIH (Japan Neurosurgical Society guidelines) and undergoing shunt placement between 2008 and 2013 in a centre of reference for neurosurgery in Spain. Clinical improvement was classified in 4 categories (resolution, partial improvement, equivocal improvement, and no improvement); functional outcome was assessed on the modified Rankin scale (mRS).
The study included 29 patients with a mean age of 73.9 years; 62.1% were male and 65.5% had hypertension. Clinical improvement (complete or partial) was observed in 58% after one year and in 48% by the end of the follow-up period (mean follow-up time was 37.8 months). Older age, presence of hypertension, and surgery-related complications were more prevalent in the group responding poorly to treatment. One patient died, 20.7% experienced severe complications, and 69% were dependent (mRS ≥ 3) by the end of the follow-up period. Age at diagnosis was independently associated with poorer clinical response at one year and a higher degree of dependency by the end of follow-up.
Symptomatic benefits offered by VPS were partial and transient; treatment was associated with a high complication rate and poor functional outcomes in the long term, especially in the oldest patients.