Hereditary gastric and pancreatic cancer predisposition syndromes

• Published in: Gastroenterología y hepatología Vol. 39; no. 7; p. 481
• Main Authors: Leoz, María Liz, Sánchez, Ariadna, Carballal, Sabela, Ruano, Lucía, Ocaña, Teresa, Pellisé, María, Castells, Antoni, Balaguer, Francesc, Moreira, Leticia
• Format: Journal Article
• Language: Spanish
• Published: Spain 01-08-2016
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - genetics; Breast Neoplasms - genetics; Colorectal Neoplasms - genetics; Cystic Fibrosis - complications; Cystic Fibrosis - genetics; Early Detection of Cancer; Endoscopy, Digestive System; Female; Forecasting; Genes, Neoplasm; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Humans; Male; Melanoma - genetics; Mutation; Neoplasms, Multiple Primary - genetics; Neoplastic Syndromes, Hereditary - diagnosis; Neoplastic Syndromes, Hereditary - genetics; Ovarian Neoplasms - genetics; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - genetics; Risk; Stomach Neoplasms - diagnosis; Stomach Neoplasms - genetics; Cáncer gástrico hereditario; Hereditary gastric cancer; Familial cancer; Hereditary pancreatic cancer; Cáncer familiar; Cáncer pancreático hereditario
• ISSN: 0210-5705
• DOI: 10.1016/j.gastrohep.2015.11.009

The most common hereditary gastrointestinal cancers are colorectal, mainly hereditary nonpolyposis colorectal cancer (Lynch syndrome) and familial adenomatous polyposis. Other extracolonic neoplasms, including the gastric and pancreatic adenocarcinomas, are less well known and studied because they account for a relatively small percentage of hereditary gastrointestinal cancers. Nonetheless, they merit special attention because of the high associated morbidity and mortality rates. We review the hereditary and familial syndromes associated with gastric and pancreatic cancers with a view to improving knowledge and understanding of these diseases, in order to heighten diagnostic suspicion and thus implement appropriate diagnostic strategies, screening, surveillance and treatment.