Current concepts for experimental micro-CT in small animals

• Published in: RöFo : Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebende Verfahren Vol. 182; no. 5; p. 390
• Main Authors: Bag, S, Schambach, S J, Boll, H, Schilling, L, Groden, C, Brockmann, Marc Alexander
• Format: Journal Article
• Language: German
• Published: Germany 01-05-2010
• Subjects: Angiography - instrumentation; Angiography - methods; Animals; Cardiac-Gated Imaging Techniques - instrumentation; Cardiac-Gated Imaging Techniques - methods; Contrast Media - administration & dosage; Disease Models, Animal; Equipment Design; Image Enhancement - instrumentation; Image Enhancement - methods; Image Processing, Computer-Assisted - instrumentation; Image Processing, Computer-Assisted - methods; Imaging, Three-Dimensional - instrumentation; Imaging, Three-Dimensional - methods; Mice; Rats; Respiratory-Gated Imaging Techniques - instrumentation; Respiratory-Gated Imaging Techniques - methods; Sensitivity and Specificity; X-Ray Microtomography - instrumentation; X-Ray Microtomography - methods
• ISSN: 1438-9010
• DOI: 10.1055/s-0029-1245301

The number of publications describing the use of micro-computed tomography (microCT) for preclinical in vivo imaging of small animals has risen considerably within the last few years. The purpose of this review is to familiarize the reader with the basic principles of microCT, to present successful experimental approaches in order of the evaluated organ system, and to highlight limitations that need to be considered when planning microCT-based studies.