Pharmacokinetics of biological tags in a case of acute valpromide self poisoning

We report the case of a 35-year-old woman hospitalized in intensive care unit after valpromide self-poisoning (Dépamide). The dose supposed to be taken was 15 g. The patient eleven hours after ingestion, presented, a coma with bilateral non-reactive mydriasis, justifying intubation and mechanical ve...

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Bibliographic Details
Published in:	Annales de biologie clinique (Paris) Vol. 68; no. 2; p. 234
Main Authors:	Commandeur, Diane, Danguy Des Deserts, Marc, Giacardi, Christophe, Eyrieux, Sandrine, Ould-Ahmed, Mehdi, Drouillard, Isabelle
Format:	Journal Article
Language:	French
Published:	France 01-03-2010
Subjects:	Acidosis - chemically induced Adult Ammonia - blood Anticonvulsants - poisoning Carnitine - therapeutic use Female Humans Lactates - blood Poisoning - blood Respiration, Artificial Time Factors Treatment Outcome Valproic Acid - analogs & derivatives Valproic Acid - blood Valproic Acid - pharmacokinetics Valproic Acid - poisoning
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Summary:	We report the case of a 35-year-old woman hospitalized in intensive care unit after valpromide self-poisoning (Dépamide). The dose supposed to be taken was 15 g. The patient eleven hours after ingestion, presented, a coma with bilateral non-reactive mydriasis, justifying intubation and mechanical ventilation. An acidosis (pH = 7.24), a hyperlactatemia (2.72 mmol/L), a hyperammonemia (328.9 micromol/L), and were diagnosed valproic acid plasmatic concentration was 1190 microg/mL at 22 hours. Symptomatic treatment and L-carnitine therapy (50 mg/kg/12h) normalized the action of biological abnormalities and allowed disappearance of symptoms; the patient was extubated after 46 hours, and outcome from intensive care unit at 65 hours.
ISSN:	0003-3898
DOI:	10.1684/abc.2010.0421