Novel mRNA isoforms of the sodium channels Na(v)1.2, Na(v)1.3 and Na(v)1.7 encode predicted two-domain, truncated proteins

The expression of voltage-gated sodium channels is regulated at multiple levels, and in this study we addressed the potential for alternative splicing of the Na(v)1.2, Na(v)1.3, Na(v)1.6 and Na(v)1.7 mRNAs. We isolated novel mRNA isoforms of Na(v)1.2 and Na(v)1.3 from adult mouse and rat dorsal root...

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Bibliographic Details
Published in:	Neuroscience Vol. 155; no. 3; pp. 797 - 808
Main Authors:	Kerr, N C H, Holmes, F E, Wynick, D
Format:	Journal Article
Language:	English
Published:	United States 26-08-2008
Subjects:	Amino Acid Motifs - genetics Amino Acid Sequence Animals Animals, Newborn Axotomy - methods Brain - metabolism Cloning, Molecular - methods Computational Biology - methods Exons Ganglia, Spinal - metabolism Gene Expression - physiology Gene Expression Regulation - physiology Male Mice Mice, Inbred C57BL Models, Molecular Molecular Sequence Data Protein Isoforms - genetics Protein Isoforms - metabolism Rats Rats, Wistar RNA Splicing RNA, Messenger - genetics RNA, Messenger - metabolism Sodium Channels - classification Sodium Channels - genetics
Online Access:	Get full text
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