Transplantation of allogenic limbal epithelial stem cells cultivated ex vivo on amniotic membrane: case report

Case report of a patient who developed failure of an allogenic living related conjunctival limbal transplantation in the right eye after an episode of epidemic keratoconjunctivitis. After a few months, she underwent transplantation of allogenic limbal epithelial stem cells cultivated ex vivo on amni...

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Bibliographic Details
Published in:	Arquivos brasileiros de oftalmologia Vol. 72; no. 2; pp. 254 - 256
Main Authors:	Gomes, José Alvaro Pereira, Pazos, Henrique Santiago Baltar, Silva, André Berger Emiliano, Cristovam, Priscila Cardoso, Belfort Júnior, Rubens
Format:	Journal Article
Language:	Portuguese
Published:	Brazil 01-03-2009
Subjects:	Adult Stem Cells - transplantation Amnion Cell Culture Techniques - methods Epithelial Cells - transplantation Female Humans Keratoconjunctivitis - surgery Limbus Corneae - cytology Male Middle Aged Transplantation, Homologous Treatment Outcome
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Summary:	Case report of a patient who developed failure of an allogenic living related conjunctival limbal transplantation in the right eye after an episode of epidemic keratoconjunctivitis. After a few months, she underwent transplantation of allogenic limbal epithelial stem cells cultivated ex vivo on amniotic membrane (first case in Brazil). The patient evolved with total corneal epithelialization and improvement of the visual acuity. Three months after the surgery, peripheral superficial neovascularization with worsening of the corneal transparency was observed. The vision remained 0.1 after one year of the transplantation.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Report-3 ObjectType-Case Study-4
ISSN:	1678-2925
DOI:	10.1590/S0004-27492009000200025