RNA binding proteins in the RNA interference phenomenon

The ability of short RNAs (21-27 nucleotides) to silence genes containing homologous nucleotide sequences is related to RNA silencing. The pathways of short RNAs (siRNA and microRNA) biogenesis from their precursors, double stranded and hairpin RNAs respectively, are briefly reviewed. The functionin...

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Bibliographic Details
Published in:	Molekuliarnaia biologiia Vol. 40; no. 4; p. 595
Main Authors:	Kotel'nikov, R N, Shpiz, S G, Kalmykova, A I, Gvozdev, V A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-2006
Subjects:	Animals Gene Silencing Humans MicroRNAs - physiology Nucleic Acid Conformation Ribonuclease III - metabolism RNA Helicases - metabolism RNA Interference - physiology RNA Processing, Post-Transcriptional RNA, Double-Stranded - metabolism RNA, Small Interfering - physiology RNA-Binding Proteins - physiology RNA-Induced Silencing Complex - physiology
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Summary:	The ability of short RNAs (21-27 nucleotides) to silence genes containing homologous nucleotide sequences is related to RNA silencing. The pathways of short RNAs (siRNA and microRNA) biogenesis from their precursors, double stranded and hairpin RNAs respectively, are briefly reviewed. The functioning of specific RNA binding domains found for the first time in the proteins operating in RNA interference (RNAi) is considered. The interactions of these domains with the earlier well known RNA binding modules in RNAi proteins are described.
ISSN:	0026-8984