Mechanisms of lability of neurological symptoms in multiple sclerosis

Pathophysiological peculiarities of demyelinated axons determine their high sensitivity to different exogenous factors and are the reason of instability of neurological signs in MS. One of the typical MS sing is high sensitivity to elevated temperature of the body. Even temporary elevation in body t...

Full description

Saved in:

Bibliographic Details
Published in:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. Suppl; p. 15
Main Authors:	Peresedova, A V, Baĭdina, E V, Trifonova, O V, Aĭzenberg, I V, Gnezditskiĭ, V V, Barkhatova, V P, Chernikova, L A, Zavalishin, I A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2002
Subjects:	Adult Axons - pathology Body Temperature - physiology Demyelinating Diseases - pathology Event-Related Potentials, P300 - physiology Female Humans Ion Channels - physiology Male Multiple Sclerosis - diagnosis Multiple Sclerosis - physiopathology Neural Conduction - physiology Severity of Illness Index
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Pathophysiological peculiarities of demyelinated axons determine their high sensitivity to different exogenous factors and are the reason of instability of neurological signs in MS. One of the typical MS sing is high sensitivity to elevated temperature of the body. Even temporary elevation in body temperature may cause changes in impulse conduction in demyelinated fibres, which was proved by studies of evoked potentials and stabilometric studies. These disturbances may be associated with disorder of ions channels function. The role of other factors (metabolic and immunological disturbances, levels of cytokines and neurotransmitters) in temporary block of nerve conduction in MS is discussed. Further studies of the mechanisms of the lability of neurological sings in MS may lead to elaboration of new approaches to MS treatment.
ISSN:	1997-7298