Influence of peroxidation products of liposomal lipids on antibacterial activity of liposomes

The dynamics of accumulation of lipid peroxidation products (LPPs) in suspensions of phosphatidyl choline-cholesterol liposomes at various acidity levels was studied. It was shown that intensity of the accumulation of LPPs was inversely proportional to the suspension pH. When the liposomes were incu...

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Bibliographic Details
Published in:	Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 37; no. 11; p. 8
Main Authors:	Mel'iantseva, L P, Kreĭnes, V M, Shraer, T I, Lagunova, N T, Ul'iantseva, I M
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-11-1992
Subjects:	Anti-Bacterial Agents - pharmacology Cholesterol - metabolism Hydrogen-Ion Concentration Lipid Peroxidation - physiology Liposomes - metabolism Liposomes - pharmacology Phosphatidylcholines - metabolism Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - growth & development
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Summary:	The dynamics of accumulation of lipid peroxidation products (LPPs) in suspensions of phosphatidyl choline-cholesterol liposomes at various acidity levels was studied. It was shown that intensity of the accumulation of LPPs was inversely proportional to the suspension pH. When the liposomes were incubated together with the cells of Pseudomonas aeruginosa, there was a decrease in the level of LPPs in comparison to that in the suspension which did not contain bacterial cells. The accumulation of LPPs in the incubation medium correlated with the bacteria death rate in the suspension. There was a direct relationship of the antibacterial activity of the liposomal suspension on its content of LPPs.
ISSN:	0235-2990