A comparison of the hypolipidemic action of probucol at doses of 500 and 1000 mg/day in moderate hyperlipoproteinemia

• Published in: Terapevtic̆eskii arhiv Vol. 70; no. 8; p. 17
• Main Authors: Tvorogova, M G, Lupanov, V P, Nuraliev, E Iu, Zaĭtseva, T M, Kukharchuk, V V, Titov, V N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1998
• Subjects: Adult; Aged; Apolipoproteins - blood; Combined Modality Therapy; Diet, Fat-Restricted; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Hyperlipoproteinemias - blood; Hyperlipoproteinemias - diet therapy; Hyperlipoproteinemias - drug therapy; Hypolipidemic Agents - administration & dosage; Hypolipidemic Agents - blood; Lipids - blood; Male; Middle Aged; Probucol - administration & dosage; Probucol - blood; Time Factors
• ISSN: 0040-3660

Evaluation of effectiveness of hypolipidemic action of probucol in doses 500 and 1000 mg/day and comparison of probucol blood concentrations on the treatment month 3 and 6.
Probucol (Akrikhin, Russia) was given to 41 patients with primary hypercholesterolemia in a dose 500 mg/day. 3 months later the patients were divided into two groups. Group 1 patients exhibited a > 10% decrease in cholesterol levels and continued to take probucol in the dose 500 mg/day. Group 2 patients were crossed over to higher cholesterol dose--up to 1000 mg/day. Lipids levels were measured by enzyme tests, apoproteins--by immunoturbidimetry and immunodiffusion, probucol concentrations--by high-performance liquid chromatography.
After 3 months of treatment, cholesterol lowered by 14.3 and 9.2% in groups 1 and 2, respectively. After 6 months, by 19.7 and 12.9%, respectively. Probucol concentrations in blood were higher after 6 months of treatment than after 3 months in both groups. No significant differences existed between the groups by probucol concentrations in 3 and 6 months.
Hypolipidemic effect of probucol depended on the individual features of lipoproteins metabolic disorders rather than the drug blood concentration. Larger probucol doses fail to reduce cholesterol further.