Spectral studies of beta-melanocyte-stimulating hormone and beta-lipotropic hormone fragment

Secondary structure of beta-melanocyte-stimulating hormone was studied by circular dichoism and infra-red spectroscopy. Left-helical conformation of poly-L-proline II type which was stabilized by temperature reduction was found in aqueous solution; in 60% ethanole the quota of this structure sharply...

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Bibliographic Details
Published in:	Biofizika Vol. 21; no. 2; p. 233
Main Authors:	Makarov, A A, Esipove, N G, Pankov iuA, Lobachev, V M, Grishkovskiĭ, B A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-1976
Subjects:	beta-Lipotropin Circular Dichroism Melanocyte-Stimulating Hormones Molecular Conformation Spectrophotometry, Infrared
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Summary:	Secondary structure of beta-melanocyte-stimulating hormone was studied by circular dichoism and infra-red spectroscopy. Left-helical conformation of poly-L-proline II type which was stabilized by temperature reduction was found in aqueous solution; in 60% ethanole the quota of this structure sharply decreased. The investigation of hormone films at different values of relative humidity (in the course of H--D metabolism) made it possible to discover a twisted beta-form and an elongated helix of poly-L-proline II type. Temperature induced changes of circular dichroism spectra specify the peculiarities of poly-L-proline II conformation in C-end fragment of beta-lipotropic hormone.
ISSN:	0006-3029