Connective tissue responses to some heavy metals. I: Sodium loaded ion exchange beads as a control: histology and ultrastructure

Ion exchange resin beads (Amberlite IR-120) were implanted into loose connective tissue as the vehicle for cations in both control and experimental studies. Beads were loaded with sodium for control purposes or with the metal of interest for subsequent experimental studies. When single control beads...

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Bibliographic Details
Published in:	British journal of experimental pathology Vol. 68; no. 3; pp. 277 - 289
Main Authors:	ELLENDER, G, HAM, K. N
Format:	Journal Article
Language:	English
Published:	London Lewis 01-06-1987
Subjects:	Animals Biological and medical sciences Cation Exchange Resins Cations - administration & dosage Cations - pharmacology Chemical and industrial products toxicology. Toxic occupational diseases Connective Tissue - drug effects Connective Tissue - ultrastructure Ear, External Fibroblasts - ultrastructure Inflammation - pathology Ion Exchange Resins Macrophages - ultrastructure Male Medical sciences Metals and various inorganic compounds Methods Microscopy, Electron Pharmaceutical Vehicles Polystyrenes Rats Rats, Inbred Strains Sodium - pharmacology Space life sciences Time Factors Toxicology Connective tissue Transmission electron microscopy Implant Toxicity Ultrastructure Histology Inflammation Ion exchange resin Heavy metal
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Summary:	Ion exchange resin beads (Amberlite IR-120) were implanted into loose connective tissue as the vehicle for cations in both control and experimental studies. Beads were loaded with sodium for control purposes or with the metal of interest for subsequent experimental studies. When single control beads were implanted in the loose connective tissue of the rat pinna, they were well accepted by tissue and permitted rapid healing. The bead implantation initially produced minimal inflammatory disruption and subsequent repair at the bead-tissue interface which rapidly matured leaving no fibro-collagenous capsule. Some minor geometric rearrangement occurred in the alignment of the connective tissue to compensate for the physical presence of the bead. This system provides a valid control for studies of the effects of metal cations on tissue inflammation and repair--free from anionic complications, surface phenomena or systemic interference.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-1021