Maternal vitamin B 3 and C intake in pregnancy influence birth weight at term

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 91-92; p. 111444
• Main Authors: Souza, Rafaela Cristina Vieira E, Miranda, Cristianny, Dos Santos, Luana Caroline
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01-11-2021
• Subjects: Babies; Birth Weight; Body Mass Index; Body size; Body weight gain; Confidence intervals; Cross-Sectional Studies; Diet; Dietary intake; Education; Energy consumption; Energy Intake; Fatty acids; Female; Food; Food intake; Fruits; Genetic crosses; Gestational age; Gestational diabetes; Humans; Male; Males; Mothers; Nutrients; Nutrition research; Offspring; Parity; Physical activity; Postpartum period; Pregnancy; Prenatal care; Questionnaires; Regression models; Socioeconomic factors; Statistical analysis; Variance analysis; Vitamin B; Vitamins; Womens health; United States > US; Pregnancy; Birth Weight; Niacinamide; Nutrients; Ascorbic Acid
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2021.111444

The objective of this study was to examine the influence of maternal nutrient intake during pregnancy on the baby's birth weight at term.
A cross-sectional study design was used to evaluate a sample of women aged 18 to 44 y in the postpartum period in a public maternity department (2018-2019), with dietary intake collected by a validated food frequency questionnaire (n = 626 mother-offspring pairs). A multivariable linear regression model was used to identify the influence of nutrient intake during pregnancy on the baby's birth weight at term. The model was adjusted for maternal energy intake, education level, gestational age, physical activity, and supplementation during pregnancy.
Maternal intake of vitamins B
and C was associated with an increase in birth weight (respectively, β = 0.01; 95% confidence interval [CI], 0.01-0.02; P = 0.01; and β = 0.01; 95% CI, 0.01-0.02; P = 0.02). Prepregnancy body mass index (β = 0.01; 95% CI, 0.01-0.02; P = 0.001), gestational weight gain (β = 0.02; 95% CI, 0.01-0.02; P < 0.001), parity (β = 0.05; 95% CI, 0.02-0.09; P = 0.001), and male babies (β = 0.08; 95% CI, 0.01-0.02; P = 0.02) also contributed to increase birth weight. These variables explained about 27% of the variation of this outcome (adjusted R
 = 0.27, P < 0.001).
Our findings provide evidence that maternal intake of vitamins B
and C influences increased birth weight. In addition, prepregnancy body mass index, gestational weight gain, parity, and male babies contribute to the same outcome.