Evaluation of Immunogenicity of Clostridium perfringens Type B Toxoid and Inactivated FMD (O) Virus with Adjuvant (ISA70-MF59)

• Published in: Archives of Razi Institute Vol. 78; no. 3; pp. 907 - 913
• Main Authors: Araghi, A, Taghizadeh, M, Hosseini Doust, S R, Paradise, A, Azimi Dezfouli, S M
• Format: Journal Article
• Language: English
• Published: Iran 01-06-2023
• Subjects: Adjuvants, Immunologic - pharmacology; Animals; Clostridium perfringens; Foot-and-Mouth Disease - prevention & control; Toxoids; Viral Vaccines; Combination vaccine; MF59; ISA70; FMD; Clostridium perfringens
• ISSN: 2008-9872
• DOI: 10.22092/ARI.2022.360215.2565

Foot and mouth disease (FMD) and enterotoxemia are important diseases of hoofed animals. Vaccination against livestock pathogens, especially these two diseases, plays a key role in the prevention and control of these diseases. The use of combined vaccines with the aim of creating a better immune response and producing cheaper vaccines is a great contribution to Vaccine industry. This research aimed to compare the immunogenicity of FMD (O) and
type B toxoid along with adjuvant (MF59) and Montanide (ISA70) to create the best immunogenicity. To investigate the immune responses of vaccines, it was injected into an animal model, and the antibody titer was measured by enzyme-linked immunosorbent assay (ELISA) test and VN antibody titer. The results showed that the formulation with MF59 adjuvant brought more stable immunogenicity against FMD and
type B, and the length of the immunogenicity period also increased significantly. Therefore, the combined vaccine (
+ FMD) could play a major role invaccine industry as an alternative vaccine against
and FMD in livestock.