A new prognostic score system of hepatocellular carcinoma following hepatectomy

• Published in: Zhōnghuá zhŏngliú zázhì Vol. 39; no. 12; p. 903
• Main Authors: Wang, Y K, Bi, X Y, Li, Z Y, Zhao, H, Zhao, J J, Zhou, J G, Huang, Z, Zhang, Y F, Li, M X, Chen, X, Wu, X L, Mao, R, Hu, X H, Hu, H J, Liu, J M, Cai, J Q
• Format: Journal Article
• Language: Chinese
• Published: China 23-12-2017
• Subjects: Alkaline Phosphatase - blood; alpha-Fetoproteins - analysis; Blood Loss, Surgical; Carcinoma, Hepatocellular - blood; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - secondary; Carcinoma, Hepatocellular - surgery; Disease-Free Survival; Hepatectomy - mortality; Humans; Liver Function Tests; Liver Neoplasms - blood; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Liver Neoplasms - surgery; Lymphatic Metastasis; Multivariate Analysis; Neoplasm Recurrence, Local; Prognosis; Proportional Hazards Models; Retrospective Studies; Risk Factors; ROC Curve; Tumor Burden; Prognosis; Liver neoplasms; Prognostic score system; Hepatectomy
• ISSN: 0253-3766
• DOI: 10.3760/cma.j.issn.0253-3766.2017.12.005

To establish a new scoring system based on the clinicopathological features of hepatocellular carcinoma (HCC) to predict prognosis of patients who received hepatectomy.
A total of 845 HCC patients who underwent hepatectomy from 1999 to 2010 at Cancer Hospital, Chinese Academy of Medical Sciences were retrospectively analyzed. 21 common clinical factors were selected in this analysis. Among these factors, the cut-off values of alpha-fetoprotein (AFP), alkaline phosphatase (ALP) and intraoperative blood loss were evaluated by using a receiver operating characteristic (ROC) curve analysis.The Kaplan-Meier method and Cox regression model were used to evaluate the independent risk factors associated with the prognosis of HCC patients after hepatectomy. HCC postoperatively prognostic scoring system was established according to the minimum weighted method of these independent risk factors, and divided the patients into 3 risk groups, including low-risk, intermediate-risk and high-risk group. The relapse-free surviva