Impact of maternal hepatitis B surface antigen carrier status on preterm delivery in southern China

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 32; no. 9; p. 1369
• Main Authors: Lu, Yongping, Chen, Youpeng, Xiao, Xiaomin, Liang, Xujing, Li, Jian, Huang, Simin, Chen, Xin, Hocher, Berthold
• Format: Journal Article
• Language: Chinese
• Published: China 01-09-2012
• Subjects: Adult; Carrier State; Case-Control Studies; Female; Hepatitis B Surface Antigens - blood; Humans; Pregnancy; Pregnancy Complications, Infectious; Premature Birth - etiology; Risk Factors; Young Adult
• ISSN: 1673-4254

To explore the impact of maternal hepatitis B surface antigen (HBsAg) carrier status on the occurrence of preterm birth.
We analyzed pregnancy-related complications, outcomes and fetal growth index in 188 HBsAg positive singleton pregnant women during the period of May 2009 to July 2011, with 265 HBsAg-negative women with singleton pregnancies in the same period serving as controls.
The HBsAg-positive pregnant women showed a significantly higher incidence of placenta praevia than the control group (2.66% vs 0%, P=0.03), and the incidence of preterm delivery (<37 weeks) was also significantly higher in HBsAg-positive group (12.23% vs 6.04%, P=0.02). The incidences of gestational hypertension, preeclampsia, gestational diabetes mellitus, abnormal glucose tolerance, premature rupture of membranes, cesarean delivery, and postpartum hemorrhage showed no significant differences between the two groups (P>0.05), nor did the fetal birth weight, height, head circumference or Apgar scores at 1, 5, and 10 min (P>0.05). L