Lung cancer screening with low dose CT requires careful consideration

Results from the American National Lung Screening Trial (NLST) show a significant reduction in lung cancer and all-cause mortality in a high risk population screened with annual low-dose CT. Handling of pulmonary nodules, false positive tests, overdiagnosis, psychosocial consequences and cost-effici...

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Bibliographic Details
Published in:	Ugeskrift for læger Vol. 176; no. 42
Main Authors:	Saghir, Zaigham, Dirksen, Asger, Ashraf, Haseem, Bach, Karen Skjøldstrup, Brodersen, John, Clementsen, Paul Frost, Døssing, Martin, Hansen, Hanne, Kofoed, Klaus Fuglsang, Larsen, Klaus Richter, Mortensen, Jann, Rasmussen, Jakob Fraes, Thomsen, Laura Hohwü, Wille, Mathilde Marie Winkler, Seersholm, Niels, Skov, Birgit Guldhammer, Thorsen, Hanne, Tønnesen, Philip, Pedersen, Jesper Holst
Format:	Journal Article
Language:	Danish
Published:	Denmark 13-10-2014
Subjects:	Cost-Benefit Analysis Diagnostic Errors Early Detection of Cancer False Positive Reactions Humans Lung Neoplasms - diagnosis Lung Neoplasms - diagnostic imaging Mass Screening - economics Mass Screening - psychology Mass Screening - standards Radiation Dosage Risk Factors Smoking - psychology Tomography, X-Ray Computed - methods
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Summary:	Results from the American National Lung Screening Trial (NLST) show a significant reduction in lung cancer and all-cause mortality in a high risk population screened with annual low-dose CT. Handling of pulmonary nodules, false positive tests, overdiagnosis, psychosocial consequences and cost-efficiency etc. are all aspects that require careful consideration. This paper gives an overview of the current knowledge on these issues. Before a recommendation can be made, we need an overall evaluation of both the benefits and harms in CT screening for lung cancer.
ISSN:	1603-6824