The blocking effects of small interfering RNAs on RS-1 gene functions of herpes simplex virus type 2: new perspectives for targeted antiviral exposure

A new target has been revealed for therapy for herpes simplex type 2. The target is RS1 mRNA whose activation is a key stage in regulating the expression of the early genes of herpes simplex virus type 2 (HSV-2). The targeted knockdown of the function of this gene by small interfering RNAs (siRNAs)...

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Bibliographic Details
Published in:	Voprosy virusologiĭ Vol. 57; no. 3; p. 14
Main Authors:	L'vov, N D, Bavykin, A S, Mel'nichenko, A V, Karpukhin, A V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-2012
Subjects:	Animals Antiviral Agents - administration & dosage Cercopithecus aethiops Gene Expression Regulation, Viral Gene Knockdown Techniques Herpesvirus 1, Human - drug effects Herpesvirus 2, Human - drug effects Herpesvirus 2, Human - genetics Humans Immediate-Early Proteins - genetics RNA, Messenger - antagonists & inhibitors RNA, Messenger - genetics RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics Vero Cells Virus Replication - drug effects
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Summary:	A new target has been revealed for therapy for herpes simplex type 2. The target is RS1 mRNA whose activation is a key stage in regulating the expression of the early genes of herpes simplex virus type 2 (HSV-2). The targeted knockdown of the function of this gene by small interfering RNAs (siRNAs) has been found to result in the complete suppression of HSV-2 infection. The designed interfering RNAs are able to interact with both HSV-1 and HSV-2. The findings suggest that siRNAs have protective properties against the cytopathic effect of HSV-2 and cause no toxicity to infected Vero cells.
ISSN:	0507-4088