A case of disseminated carcinomatosis of bone marrow treated by S-1 and cisplatin after distal gastrectomy for early gastric cancer

Patients with bone metastasis originating from gastric cancer experience complications from DIC. They are treated with anticoagulation therapy or platelet transfusion, but their prognosis is poor. Our case was a 50-year-old male who had undergone distal gastrectomy for early gastric cancer[pT1a(M)N0...

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Bibliographic Details
Published in:	Gan to kagaku ryoho Vol. 39; no. 5; p. 813
Main Authors:	Tsuji, Kunihiro, Doyama, Hisashi, Yamada, Shinya, Kaneko, Yoshifumi, Takemura, Kenichi, Tsuji, Shigetsugu, Tominaga, Kei, Inagaki, Satoko, Hayashi, Tomoyuki, Ito, Renma, Nakanishi, Hiroyoshi, Kitou, Yousuke, Takeda, Yasuhito, Yamamoto, Michihiro, Inaki, Noriyuki, Yamada, Tetsuji, Niwa, Hideki, Katayanagi, Kazuyoshi, Kurumaya, Hiroshi
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-05-2012
Subjects:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bone Marrow Neoplasms - complications Bone Marrow Neoplasms - drug therapy Carcinoma - drug therapy Carcinoma - pathology Cisplatin - administration & dosage Disseminated Intravascular Coagulation - etiology Drug Combinations Fatal Outcome Gastrectomy Humans Male Middle Aged Neoplasm Staging Oxonic Acid - administration & dosage Stomach Neoplasms - drug therapy Stomach Neoplasms - pathology Stomach Neoplasms - surgery Tegafur - administration & dosage
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Summary:	Patients with bone metastasis originating from gastric cancer experience complications from DIC. They are treated with anticoagulation therapy or platelet transfusion, but their prognosis is poor. Our case was a 50-year-old male who had undergone distal gastrectomy for early gastric cancer[pT1a(M)N0M0, pStage I a]ten years previously. He was admitted to our hospital complaining of backache. As a result of his examination, he was diagnosed with disseminated carcinosis of bone marrow with DIC as a postoperative recurrence of gastric cancer. The patient was treated with combination chemotherapy of S-1 and cisplatin(S-1 80 mg/body, po, day 1-21 and cisplatin 50mg/body, iv, day 8). After one course of treatment, DIC was resolved and his pain was relieved. He survived for about nine months. S-1 and cisplatin are considered to be effective for disseminated carcinosis of bone marrow.
ISSN:	0385-0684