A case of necrotizing fasciitis developed in a patient with recurrent rectal cancer treated with chemotherapy

A fifty-two-year-old female with advanced rectal cancer underwent low anterior resection and hysterectomy. After local pelvic recurrence, she underwent radiation therapy(50 Gy in total), and then chemotherapy(XELOX+bevacizumab)was started. However, left femoral pain developed after the second course...

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Bibliographic Details
Published in:	Gan to kagaku ryoho Vol. 40; no. 5; p. 663
Main Authors:	Shimada, Ayako, Nakamura, Takeshi, Ishii, Masatsugu, Chiba, Naokazu, Ishikawa, Shuji, Arisawa, Yoshito, Hashimoto, Mitsumasa
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-05-2013
Subjects:	Antibodies, Monoclonal, Humanized - administration & dosage Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab Combined Modality Therapy Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Fasciitis, Necrotizing - etiology Fatal Outcome Female Fluorouracil - administration & dosage Fluorouracil - analogs & derivatives Humans Middle Aged Rectal Neoplasms - complications Rectal Neoplasms - drug therapy Rectal Neoplasms - pathology Rectal Neoplasms - surgery Recurrence
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Summary:	A fifty-two-year-old female with advanced rectal cancer underwent low anterior resection and hysterectomy. After local pelvic recurrence, she underwent radiation therapy(50 Gy in total), and then chemotherapy(XELOX+bevacizumab)was started. However, left femoral pain developed after the second course of chemotherapy, and necrotizing fasciitis associated with lower bowel perforation was found. Although bowel perforation is known as a serious side-effect of bevacizumab, its association with fasciitis is rare.
ISSN:	0385-0684