Fatal outcome of a hypersensitivity reaction to paclitaxel: a critical review of premedication regimens

• Published in: British journal of cancer Vol. 90; no. 2; pp. 304 - 305
• Main Authors: Kloover, J S, den Bakker, M A, Gelderblom, H, van Meerbeeck, J P
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 26-01-2004
• Subjects: antitumor agents; hypersensitivity; paclitaxel
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/sj.bjc.6601301

Hypersensitivity reactions (HSRs) to paclitaxel are frequently encountered in patients receiving this antitumour drug. Administration of histamine H1- and H2-receptor antagonists and corticosteroids has been shown to reduce significantly the risk of developing an HSR in patients receiving taxanes. In this case report, we describe the fatal outcome of an HSR in a patient receiving paclitaxel despite short-course premedication. The level of evidence supporting the short-course i.v. premedication schedule is challenged, as it is not compatible with the pharmacokinetic properties of dexamethasone.