The expression and significance of programmed cell death 5 and Bcelllymphoma/lewkmia-2 in sinonasal squamous cell carcinoma

• Published in: Lin chuang er bi yan hou ke za zhi Vol. 28; no. 17; p. 1301
• Main Authors: Lu, Honglue, Wang, Chengshuo, Hao, Lingling, Yin, Guiru, Hao, Ran
• Format: Journal Article
• Language: Chinese
• Published: China 01-09-2014
• Subjects: Apoptosis Regulatory Proteins - metabolism; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - mortality; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - mortality; Humans; Neoplasm Proteins - metabolism; Papilloma, Inverted - metabolism; Paranasal Sinus Neoplasms - metabolism; Proto-Oncogene Proteins c-bcl-2 - metabolism; Squamous Cell Carcinoma of Head and Neck; Survival Rate
• ISSN: 1001-1781

To explore the expression and significance of programmed cell death 5 (PDCD5) and Bcelllymphoma/lewkmia-2(Bcl-2) in sinonasal squamous cell carcinoma (SNSCC).
Immunohistochemical method and Western Blot method was used to determine the expression of PDCD5 and Bcl-2 in specimen of SNSCC in thirty cases, sinonasal inverted papillomas (SNIP) in thirty-eight cases, and normal nasal mucosa in twenty cases.
(1) The expression of PDCD5 protein in SNSCC significantly decreased compared with SNIP and normal nasal mucosa. (2) The expression of Bcl-2 protein in SNSCC up-regulated obviously compared with SNIP and normal nasal mucosa. (3) Positive rate of PDCD5 protein and Bcl-2 protein in well, moderate and low differentiatied group is respectively 100.00%, 83.33%, 38.89% and 50.00%, 70.83% and 100.00%, the difference was statistically significant (P < 0.05). (4) In the follow-up cases, the survival rate of the patients with higher expression of PDCD5 protein was higher, but that with lower expression of Bcl-2 protein wa