A novel formulation of cisplatin (CDDP)

The study aimed to assess our newly devised CDDP delivery system designed to provide targeting potential and a sustained release of the anticancer agent. Seventy percent deacetylated chitin was applied as a drug carrier. We prepared two different types of systems with two different procedures: namel...

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Bibliographic Details
Published in:	Gan to kagaku ryoho Vol. 36; no. 12; p. 2294
Main Authors:	Sugitachi, Akio, Kimura, Yusuke, Itabashi, Tetsuya, Noda, Hironobu, Ishida, Kazushige, Nishizuka, Satoshi, Otsuka, Koki, Kashiwaba, Masahiro, Nitta, Hiroyuki, Koeda, Keisuke, Mizuno, Masaru, Sasaki, Akira, Ikeda, Kenichiro, Takamori, Yoshimori, Wakabayashi, Go
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-11-2009
Subjects:	Adhesiveness Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Cell Division - drug effects Cell Line, Tumor Chitin Cisplatin - administration & dosage Cisplatin - pharmacology Delayed-Action Preparations Humans Stomach Neoplasms - pathology
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Summary:	The study aimed to assess our newly devised CDDP delivery system designed to provide targeting potential and a sustained release of the anticancer agent. Seventy percent deacetylated chitin was applied as a drug carrier. We prepared two different types of systems with two different procedures: namely, system A with direct method and system B with indirect method. The targeting property of the system was evaluated ex vivo with measuring adhesive force between each system and human colonic mucosa. The release behavior of the CDDP from the system was examined in vitro. The anticancer activities of the released CDDP were also examined in vitro using human gastric cancer cell line, MKN-45. Each system was a viscose elastic solution. The adhesive forces of the novel systems were stronger at 37 degrees C than that of 25 degrees C. Each system provided a sustained release of CDDP. The released CDDP demonstrated effective growth suppression activity against the MKN-45 cancer cells. The novel systems basically showed a favorable targeting function and a sustained release of CDDP, which effectively provided a growth inhibition potential against human cancer cell line. Our newly devised CDDP delivery systems are promising as a novel approach to cancer chemotherapy.
ISSN:	0385-0684