Usefulness of hepatic arterial infusion chemotherapy for the patients with synchronous liver metastases from colorectal cancer

• Published in: Gan to kagaku ryoho Vol. 36; no. 12; p. 2032
• Main Authors: Kimura, Osamu, Yamamoto, Osamu, Hisamitsu, Kazunori, Yamane, Nariyuki, Hamazoe, Ryuichi
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-11-2009
• Subjects: Aged; Colorectal Neoplasms - pathology; Female; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms - drug therapy; Liver Neoplasms - mortality; Liver Neoplasms - secondary; Male; Middle Aged; Neoplasms, Multiple Primary - drug therapy; Neoplasms, Multiple Primary - secondary; Survival Rate
• ISSN: 0385-0684

We analyzed the results of hepatic arterial infusion chemotherapy (HAIC) for 24 patients with synchronous liver metastases from colorectal cancer for the last twelve years in order to investigate the usefulness of HAIC for those patients. In 8 cases with resection of liver metastases, the median survival time (MST) was 45 months, mean survival time was 53 months and a 5-year survival rate was 44%. In 16 cases without resection of liver metastases, 2 cases had complete response (CR), 10 cases had partial response (PR), 4 cases had stable disease (SD), and the response rate was 75%. There was a significant difference in the survival time of each response. MST was 25 months, and mean survival time was 38 months. According to the usefulness of HAIC for the patients with synchronous liver metastases from colorectal cancer, it seems that HAIC with effective general chemotherapy will have better results than HAIC.