T cell receptor constant alpha chain gene +1592C/T polymorphism may not be associated with IgA nephropathy

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 30; no. 10; p. 2298
• Main Authors: Li, Shi-liang, Lin, Xu, Wang, Jie, Yang, Fa-fen, You, Yan-wu, Guo, Peng-wei
• Format: Journal Article
• Language: Chinese
• Published: China 01-10-2010
• Subjects: Adolescent; Adult; Asian Continental Ancestry Group - genetics; Child; Chromosomes, Human, Pair 14; Female; Gene Frequency; Genotype; Glomerulonephritis, IGA - genetics; Humans; Kidney - pathology; Male; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Receptors, Antigen, T-Cell, alpha-beta - genetics; Young Adult
• ISSN: 1673-4254

To investigate the relationship between T cell receptor constant alpha chain (TCRCα) gene +1592C/T polymorphism and IgA nephropathy.
TCRCα +1592C/T genotypes were identified by PCR-RFLP and direct sequencing in 244 Chinese Han patients with IgA nephropathy, who were classified according to their genotype into CC (188 cases), CT (54 cases) and TT (2 cases) groups. The clinical and pathological data of the patients were analyzed in relation to the TCRCα +1592C/T genotypes.
No significant differences in the clinical and biochemical indices were found in these patients with different TCRCα gene +1592C/T genotypes. TCRCα +1592C/T polymorphism was not found to contribute to severity or manifestations of renal pathology.
TCRCα+1592C/T polymorphism may not be associated with the susceptibility to IgA nephropathy in the Chinese Han population.