Long-term results of using mononuclear fraction of autologous bone marrow cells in complex surgical treatment of patients with heart valve failure

• Published in: Vestnik hirurgii im. I.I. Grekova Vol. 170; no. 5; p. 49
• Main Authors: Davydenko, V V, Gritsenko, V V, Amosov, V I, Afanas'ev, B V, Maĭorov, N V, Lapekin, S V, Pushkarev, A A, Livinov, A P
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2011
• Subjects: Adult; Aged; Bone Marrow Cells - ultrastructure; Bone Marrow Transplantation - methods; Cell Separation; Combined Modality Therapy; Heart Valve Diseases - mortality; Heart Valve Diseases - physiopathology; Heart Valve Diseases - surgery; Humans; Male; Middle Aged; Myocardial Perfusion Imaging; Neovascularization, Physiologic; Pilot Projects; Transplantation, Autologous - methods; Treatment Outcome
• ISSN: 0042-4625

The article is devoted to long-term results of pilot clinical investigation of using mononuclear fraction of autologous bone marrow cells as an additional procedure to standard surgical treatment of heart valve failure in order to improve local perfusion and contractive ability of the myocardium. The article presents results of an analysis of findings of the examination of 7 living patients within 6 years or 7 years after operation as also data of pathologicoanatomical investigation of three dead patients. The data obtained show the safety and effectiveness of this method of cell therapy in patients with heart valve failure.